Title:	Spatial analysis of tumor images
DNr:	Berzelius-2024-129
Project Type:	LiU Berzelius
Principal Investigator:	Anna Sandström Gerdtsson <anna.sandstrom_gerdtsson@immun.lth.se>
Affiliation:	Lunds universitet
Duration:	2024-04-01 – 2024-10-01
Classification:	10203
Keywords:

Abstract

Spatial analysis of multiplex immunofluorescence images of tissue microarrays will be conducted using e.g. graph neural networks and/or other methods of spatial statistics. The objective is to generate prediction models of spatial components (e.g. cellular neighborhoods) in relation to molecular profiles established by high-plex spatial omics technologies and clincial outcomes such as survival. The long term goal is to provide spatio-molecular tumor microenvironment signatures for improved patient stratification and for guiding immuno-oncology treatments.